Estimation of infection fields and pathways for SARS-CoV-2 and its variant based on the relationship among dose-response function parameter, quantum emission rate, and basic reproductive number

The theoretical model of the relationship among dose-response function parameters, quantum emission rate, and basic reproductive number for SARS-CoV-2 was constructed. Then, using this model, infection fields and pathways for SARS-CoV-2 and its variant were estimated. The parameters of the time activity, the number of contacts by the microenvironments and groups, and the COVID-19 risk from multiple pathways in near and far fields were used. Consequently, in lower transmissibility, droplet spray transmission in the near field was dominant, whereas in higher transmissibility, transmission from inhalation of smaller aerosols in the far field was dominant. Moreover, it was suggested that transmission from droplet spray, indirect contacts, and inhalation of smaller aerosols in the near field and inhalation of smaller aerosols in the far field was dominant for the wild-type strain, while transmission from inhalation of smaller aerosols in the far field were dominant for the Delta variant. © 2022 17th International Conference on Indoor Air Quality and Climate, INDOOR AIR 2022. All rights reserved.

Exercise modulates the immune system in cardiorespiratory disease patients: Implications for clinical practice during the COVID-19 pandemic.

BACKGROUND: Patients with cardiorespiratory problems often suffer from systemic inflammation. Stress due to the disease and continuous inflammation can undermine the success of the rehabilitation program. OBJECTIVE: This review has been undertaken primarily to understand the effectiveness of exercise training on the immune system in individuals undergoing cardiorespiratory rehabilitation and its implications for further management during the COVID-19 pandemic. METHODS: Assessors analyzed related studies identified in the MEDLINE, PROQUEST, PUBMED, Cochrane Library, CINAHL, EMBASE, Google Scholar, Physiotherapy Evidence, and Science Direct databases. The studies were divided into groups focused on the effect of exercise on blood leukocytes, the anti-inflammatory effect, and the role of nutrition and exercise in resolving inflammation. RESULTS: Twenty-eight studies were included in this review. The number of studies included in each section was as follows: the effects of exercise training on leukocytes in cardiorespiratory conditions (n = 8), anti-inflammatory effect (n = 6), and the role of nutrition and exercise in resolving inflammation (n = 14). The bias risk assessment showed poor internal validity; most included studies were assigned no and unclear descriptors. CONCLUSIONS: Substantive evidence is presented that emphasizes the role of moderate-intensity exercise in boosting the immune system in patients with cardiorespiratory diseases. Exercise has anti-inflammatory effects that are vital for overall well-being and resolving longstanding inflammation. Individuals with an active lifestyle had a better pathogen immune response than more sedentary individuals. Our findings highlight the current need to investigate the long-term effects of cardiorespiratory rehabilitation programs.